Both of the two antigens were negative in 29 patients with acute T lymphoblastic leukemia and 7 patients with T/My AMLL. -, J Clin Pathol. Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. When compared with background benign B-cells, CD20 was frequently overexpressed on tumor cells (mean MFR=1.8), while CD19 expression was overall similar to background benign B-cells (mean MFR=0.9) (p=0.001). While CD20 has a higher average density of surface molecules per tumor cell, CD19 expression is more homogenous and is preserved in small CD20-negative tumor subsets and after anti-CD20 targeted … Blood Cancer J.
1989 Sep;42(9):962-72 To investigate whether the antigen levels of the B cell lineage markers CD19 and CD20 can distinguish between normal and neoplastic B cells or characterise distinct expression patterns among the chronic B cell leukaemias. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. Cortelazzo S, Ponzoni M, Ferreri AJ, Hoelzer D. Crit Rev Oncol Hematol.
Pedro Horna, Grzegorz Nowakowski, Jan Endell, Rainer Boxhammer; Comparative Assessment of Surface CD19 and CD20 Expression on B-Cell Lymphomas from Clinical Biopsies: Implications for Targeted Therapies. In contrast, the level of expression of membrane CD20 was higher than the mean (SD) value in normal B cells (94 (16) x 10(3) molecules/cell) in MCL (123 (51) x 10(3)); B-PLL (129 (47) x 10(3)); SLVL (167 (72) x 10(3)); and HCL (312 (110) x 10(3)); while it was significantly lower (65 (11) x 10(3)) in CLL compared with normal B cells and the other B cell leukaemias. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. 2019 Oct 30;3(6):e308. Aims: NIH [Distribution of antigenic aberration in the bone marrow of acute leukemia in complete remission]. doi: 10.1038/s41375-020-0792-2. NCI CPTC Antibody Characterization Program, J Immunol. doi: 10.1097/HS9.0000000000000308. Standard microbeads with different capacities to bind mouse immunoglobulins were used to convert the mean fluorescence intensity (MFI) values into number of antigen molecules/cell, expressed as antibody binding capacity (ABC). Clipboard, Search History, and several other advanced features are temporarily unavailable. Hemasphere. Quantitative analysis of CD79b, CD5 and CD19 in mature B-cell lymphoproliferative disorders. Hofland T, Endstra S, Gomes CKP, de Boer R, de Weerdt I, Bobkov V, Riedl JA, Heukers R, Smit MJ, Eldering E, Levin MD, Kater AP, Tonino SH. Blood 2019; 134 (Supplement_1): 5345. doi: https://doi.org/10.1182/blood-2019-129600.
Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. Asterisk with author names denotes non-ASH members. Blood. Biopsies from eight additional patients with persistent/recurrent B-cell lymphomas after anti-CD20 therapy (greater than 6 months after last dose) were also evaluated. Peripheral blood cells from 70 patients with B cell disorders and 17 healthy donors were analysed by quantitative flow cytometry.
2020 Apr;59(4):463-474. doi: 10.1007/s40262-019-00823-8. doi: 10.1038/bcj.2017.53. Hematology Am Soc Hematol Educ Program. In addition, CD19 or CD20 fluorescence intensities of tumor cells were normalized to background benign B-cells (internal positive control) using the median fluorescence ratio (MFR). In addition, percentages of CD19/CD20 double-negative tumor events were very small (median=0%, range=0-4.9%), and only detectable in 15 cases (32%). 1985 Aug;135(2):973-9 2020 Mar 24:10.1038/s41375-020-0792-2. | 2011 Sep;79(3):330-43. doi: 10.1016/j.critrevonc.2010.12.003. -, Leukemia.
Small lymphocytic lymphoma was intentionally excluded, given its well-described loss of CD20 expression. Both the specificity and sensitivity of CD19 were very high with a much broader reaction pattern than that of CD20 on this group of diseases. Standard microbeads with different capacities to bind mouse immunoglobulins were used to convert the mean fluorescence intensity (MFI) values into number of antigen molecules/cell, expressed as antibody binding capacity (ABC).
The difference of the fluorescence intensity between the two antigens on the cells from each patient with B lineage ALL or B/My AMLL was statistically significant (t = 20.68, P < 0.001).
Roliński J, Rupniewska ZM, Dmoszyńska A, Wasik-Szczepanek E, Bojarska-Junak A. Pol Arch Med Wewn. B- and T-cell prolymphocytic leukemia: antibody approaches.
Rust BJ, Kean LS, Colonna L, Brandenstein KE, Poole NH, Obenza W, Enstrom MR, Maldini CR, Ellis GI, Fennessey CM, Huang ML, Keele BF, Jerome KR, Riley JL, Kiem HP, Peterson CW. Of eight additional cases studied post-anti-CD20 immunotherapy (6-84 months after last dose), the percentage of antigen-positive events by tumor cells was largely preserved for both CD19 (median=99.6%, range=93.5-100%) and CD20 (median=95.7%, range=55.6-100%), similar to the pre-therapy cohort. Search for other works by this author on: © 2019 by The American Society of Hematology, Copyright ©2020 by American Society of Hematology, 627.Aggressive Lymphoma (Diffuse Large B-Cell and Other Aggressive B-Cell Non-Hodgkin Lymphomas)-Results from Retrospective/Observational Studies, https://doi.org/10.1182/blood-2019-129600.
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