Also, the syndrome is linked with an increased risk for breast cancer, varicose veins, lung disease, extragonadal germ cell tumor, and osteoporosis. I'm only one person, but there are estimates that put the figures between 1 in every 500 males and 1 in every 3000 males. Note – because of the high degree of variability of the syndrome, many of these clinical characteristics can be present at birth or they can manifest later in childhood.  In 1956 it was discovered that Klinefelter syndrome resulted from an extra chromosome. ", "Is there a cure for Klinefelter syndrome (KS)? Often there is an azoospermia present, rarely an oligospermia.  The extra X chromosome comes from the father and mother nearly equally. Jun 9, 2018 - Find information about famous people with Marfan syndrome or Klinefelter syndrome. The incidence of 49,XXXXY is one in 85,000 to 100,000 male births. From the onset of puberty, the existing testosterone deficiency can be compensated by appropriate hormone replacement therapy.  Sometimes, symptoms are more prominent and may include weaker muscles, greater height, poor coordination, less body hair, breast growth, and less interest in sex. Two of the most famous people that suffered from klinefelter syndrome were George Washington artist Lili Elbe.  These variations are extremely rare. He was born on September 27, 1987, in Ohio, and is best known as the former lead vocalist of the bands ”Attack Attack!” and ”Of Mice & Men.”.  However, it is estimated that only 25% of the individuals with Klinefelter syndrome are diagnosed throughout their lives. There must be 46 chromosomes in the body but, for women who have this health issue, they actually have more than 46 chromosomes in their body. The size of his hands may have been a manifestation of MS. Phelps won 6 gold medals at the 2004 Olympics, 8 gold medals at the 2008 Olympics, and 4 gold medals at the 2012 Olympics. The syndrome is also the main cause of male hypogonadism. Sivan is also quite popular on social media, including Instagram (where he has more than 7 million followers) and YouTube (where his audience includes over 6.2 million people). ", Eunice Kennedy Shriver National Institute of Child Health and Human Development, "How many people are affected by or at risk for Klinefelter syndrome (KS)? All content, including text, images, graphics, and information, contained on or available through this website is for general information purposes only. Also, at the 12th IAAF World Athletic Championships in Berlin, Caster won the 800m race in a best personal time of 1.55.45 seconds. Klinefelter syndrome is a genetic condition affecting males, and it often isn't diagnosed until adulthood.Klinefelter syndrome may adversely affect testicular growth, resulting in smaller than normal testicles, which can lead to lower production of testosterone. If gynecomastia is present, the surgical removal of the breast may be considered for both the psychological reasons and to reduce the risk of breast cancer. Two of the most famous people that suffered from klinefelter syndrome were George Washington artist Lili Elbe.  Often, symptoms are subtle and subjects do not realize they are affected. Consult a medical practitioner for health problems. The primary features are infertility and small poorly functioning testicles. In adults, possible characteristics vary widely and include little to no sign of affectedness, a lanky, youthful build and facial appearance, or a rounded body type with some degree of gynecomastia (increased breast tissue). For nearly 15 years, Bradford Cox has been the frontman of Deerhunter, a band from Atlanta. It can be difficult to diagnose since many sufferers have only a few typical symptoms and no specific biochemical or histologic changes. This XXY chromosome arrangement is one of the most common genetic variations from the XY karyotype, occurring in about one in 500 live male births. If you have MS, you have a 50:50 chance of passing on the condition to each of your children.  By 2010, over 100 successful pregnancies have been reported using IVF technology with surgically removed sperm material from males with KS. In the video below, Matt who has XXY Klinefelter Syndrome, talks about what he goes through on a daily basis. 38 Cool & Interesting Facts About Surgeons (Orthopedic, Plastic, Pediatric, General), Celebrities With Turner Syndrome (Missy Marlowe?). Additional chromosomal material can contribute to cardiac, neurological, orthopedic, and other anomalies. It is named after Antoine Marfan, a French doctor who first described the syndrome in 1896. Hello! A small blood sample is sufficient as test material. The signs and symptoms of KS in young boys and teenagers may include: Note – since KS can be hard to notice, many parents don’t know their child has the syndrome until he shows delays in puberty. The syndrome may also cause reduced muscle mass, reduced body and facial hair, and enlarged breast tissue. You may wonder how on earth a monarch makes our list of famous people with Klinefelter syndrome, but there are good reasons for this. Based on pictures and contemporary accounts, he may had Marfan syndrome. Some of the celebrities include - Michael Phelps and Arik Einstein. , While no cure is known, a number of treatments may help. , Some degree of language learning or reading impairment may be present, and neuropsychological testing often reveals deficits in executive functions, although these deficits can often be overcome through early intervention. It can affect physical and mental development.  It has been estimated that 50% of males with Klinefelter syndrome can produce sperm.  Often it is only at puberty that these symptoms are noticed. , Klinefelter syndrome occurs randomly.  The primary features are infertility and small poorly functioning testicles. In mammals with more than one X chromosome, the genes on all but one X chromosome are not expressed; this is known as X inactivation. , The standard diagnostic method is the analysis of the chromosomes' karyotype on lymphocytes. , Klinefelter syndrome is one of the most common chromosomal disorders, occurring in one to two per 1,000 live male births. He was a vocalist for Shleeshiyat Gesher Hayarkon (Yarkon Bridge Trio), Batzal Yarok (Green Onion), and Hahalonot Hagvohim (The High Windows).  3.1% of infertile males have Klinefelter syndrome. Klinefelter syndrome (47, XXY) is a condition that occurs in men who have an extra X chromosome, resulting in an XXY sex chromosome karyotype. He was a composer and the last great figure of the Russian Romanticism tradition. Health Guide Net provides qualitative and informative articles on health, diet, and beauty.  Women at 40 years have a four times higher risk for a child with Klinefelter syndrome than women aged 24 years. Some believe this is because of her Klinefelter syndrome. This was further clarified as XXY in 1959 by Patricia Jacobs and John Anderson Strong. , "What are common symptoms of Klinefelter syndrome (KS)? Klinefelter syndrome (47, XXY) is a condition that occurs in men who have an extra X chromosome, resulting in an XXY sex chromosome karyotype. Physical characteristics of a Klinefelter syndrome can be tall stature, low body hair and occasionally an enlargement of the breast. In the video below, Matt who has XXY Klinefelter Syndrome, talks about what he goes through on a daily basis. Often it is only at pubertythat these symptoms are noticed. Vincent was an actor that had made over 120 television and film appearances. , Affected males are often infertile, or have reduced fertility. The Klinefelter-Reifenstein-Albright syndrome.  Often it is only at puberty that these symptoms are noticed.  It’s estimated that 10% of men with Klinefelter syndrome are Autistic.  During puberty and adulthood, low testosterone levels with increased levels of the pituitary hormones FSH and LH in the blood can indicate the presence of Klinefelter syndrome.  Despite this misunderstanding of the term, however, XXY men may also have microorchidism (i.e., small testicles). , The syndrome was named after American endocrinologist Harry Klinefelter, who in 1942 worked with Fuller Albright and E. C. Reifenstein at Massachusetts General Hospital in Boston, Massachusetts, and first described it in the same year.  People with the condition have a nearly normal life expectancy. Another mechanism for retaining the extra chromosome is through a nondisjunction event during meiosis II in the egg. , The symptoms of KS are often variable; therefore, a karyotype analysis should be ordered when small testes, infertility, gynecomastia, long arms/legs, developmental delay, speech/language deficits, learning disabilities/academic issues, and/or behavioral issues are present in an individual.
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